CASCADEplus

The anticancer system build on natural supplements and traditional folk medicine.

The inventor of the CASCADEplus system, faced a simple but essential challenge: is it possible to develop a science backed anti-cancer treatment system, solely based on natural supplements, that will or may have the same or perhaps better effects as the 'classical' anticancer therapies, provided in hospitals?

So as the challenge was set, a thorough research started. First of all, by turning the World's broadest scientific database of Research.Net upside-down and to look for credible academic studies, regarding plant based substances and specific anticancer properties. The first actions gained fruitfull results, as thousands of academic studies revealed very encouraging results.

Over the past decades academic researchers, from all over the world, published numerous valuable scientific publications about cancer and cancer research. Albeit that fact, the overall progress in curing a broad variety of cancers, is going relatively slow. That seems to be a remarkable contradiction?

Many Oncologists may claim, that the obvious difference between the vast output of valuable scientific research and the rather dismal success rates in curing cancers, should be seen in the context of the complexity of cancers. That may be a too obvious answer and it doesn't require any meaningful considerations.

It may be, that the root cause of a lack of progress in anti-cancer treatments, is inherent to the complexity of cancers. Albeit that may be plausible, there seem to be other key factors. One could also ask: Is there perhaps a lack of integration of both knowledge and new insights?

The latter seems plausible. The integration of new and promising insights in anticancer therapies, is going rather slow. Especially in the healthcare systems in the Western parts of the world. The main culprits seems to be the protocolization of cancer treatments and a climate of fear; the risk of being publicly smeared as a quack.

The principle of protocolization often means: only proven therapies and medicines, based upon a broad Phase III clinical trial can be applied. This reality seems to cause a rigid approach towards a process of the integration of natural substances in Western based anticancer therapies.

In contrary to Western based anticancer treatments; in China and India they did not abandon traditional folk medicine. So in Asia there's nowadays, a solid trend visible of an integration of Western based anticancer therapies and traditional folk medicine. And this open approach is delivering encouraging if not substantial results.

So yes, the latter ultimately means that a more rapid integration of 100% natural substances, in anticancer treatments, will lead to improved clinical results. Thus cancer patients are, regarding some types of cancer, currently better of in Beijing or Mumbai, compared to Berlin and Boston.

The core principles of the CASCADEplus system. 

Within the CASCADEplus system there's a rather pragmatic approach towards the application of promising natural substances. There are four essential criteria, that need to be met before a substance can be integrated:

1. Has there been at least a credible scientific publication?

2. Is it sufficiently available?

3. Is it non-toxic and not causing any serious side effects?

4. Is the seller and or source more or less reliable? 

Furthermore, the CASCADEplus system is based upon the principle that so called 'silver bullets' against various types of cancer, do not exist. Thus a variety of substances, aimed at various (cellular)targets, is often a necessity. Proof of this principle is seen in a current trend in anticancer immunotherapies: the more types of so called immune-checkpoints are being blocked, the better the overall outcome.

See the CASCADEplus system as the following metaphor: when you encounter a burglar in your house at 02:00 AM, a single slap in his face will not be sufficient to take the guy out. Instead, the burglar may become angry and he may decide to kill you! This principle if often seen after chemo- and or radiotherapeutic interventions. After such therapeutic interventions, patients seem to be fully cured, but very often a small amount of the particular cancer cells have adapted to such therapies and have turned themselves into very malign cancer cells.

In the CASCADEplus system, the burglar will simultaneously be hit with a baseball bat, he's getting stabbed three times with a knive in his lungs, he will be shot five times in the belly and he's getting serious hits with a forehammer on both of his knees. Every vital target has to be attacked, in order to be ensured that the threat is being eliminated.

Furthermore, within the CASCADEplus approach, there's a strong focus on the body's own immunesystem; i.e. how to restore functioning of impaired Natural Killer - (NK) and T-cells. Healthy and well functioning NK- and T-cells, can eradicate virtually every type of cancer.

When immunostimulatory actions are being combined with intracellular interventions - whereby it is aimed to kill the cancer cells from within -, there's a rationale to state: a one-fits-all treatment system, based upon sole natural ingredients, against various types of cancer, could become a true reality.

And another unique feature: the CASCADEplus system can be ahead of the pharmaceutical industry. For example, in recent years an number of new and presumed key targets have been identified, regarding tumor growth and metastasis of malign cancer cells. And whereas the Pharmaceutical industry often develops a synthetic molecule against such a novel target - for a patent -, the CASCADEplus simply looks for a more 'patient friendly' plant based molecule.

So in short terms, the CASCADEplus system aims to block (ligand)receptors on cancer cells, cellular signals inside cancer cells, to block immune-checkpoints on T-cells and to remove particular immune-checkpoints on T-cells. This approach, as a integral anti-cancer treatment, is unique in its kind.  All in all, the CASCADEplus system aims to be a both unique and completely novel approach in the fight against cancers.